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By contrast, 26 of those who got a placebo progressed to active tuberculosis. Dr. Nazir Ismail, chief of tuberculosis research at South Africas National Institute of Communicable Diseases, called the vaccines 50% effectiveness reasonably good. Giving two shots one month apart, he pointed out, is simpler than current prevention practice, which requires that patients take protective antibiotics every day for a month. Also, using antibiotics for prevention increases the risk that antibiotic-resistant TB will appear, while a vaccine does not. Because so many people die of tuberculosis, Dr. Seth Berkley, chief executive of Gavi, the Vaccine Alliance, a public-private partnership that buys vaccines for poor countries, said his agency would certainly give the vaccine a hard look. Gavi already supports some vaccines that are only partly effective, he noted. For example, some vaccines for human papillomavirus, or HPV, stop only 70% of the strains of the cancer-causing virus, and a new malaria vaccine being field-tested in Africa is only 39% effective. An important question raised by the study, researchers said, is who should receive the vaccine. Tuberculosis rates vary enormously not just between countries, but even from neighborhood to neighborhood. The disease thrives in people who live in crowded conditions, inhaling one anothers germs, and the bacterium dies quickly in sunlight. Tuberculosis can be transmitted even through something as simple as a cough on a crowded bus. But the people at the highest risk include family members of patients with active tuberculosis, the doctors and nurses caring for them and, in countries where tuberculosis is common, people living or working in crowded conditions, such as prisoners and miners. But in any country, people are also at risk of infection if they have HIV, are severely malnourished, are taking immune-suppressive cancer chemotherapy or organ-transplant drugs, have diabetes or are on dialysis. The new study, however, tested the vaccine only in people who were HIV-negative and whose blood tests showed they had latent tuberculosis. But at least a quarter of the worlds population would come up positive for latent tuberculosis on a blood or skin test. The result means only that they have been exposed to tuberculosis germs some time in the past. We have no idea if they have been infected last month or 20 years ago, Raviglione said. Those infected long ago may have already have cleared their bodies of the infection. Most people who are ever going to develop active tuberculosis do so within two years of their first infection. Therefore, some prominent researchers argue that latency tests greatly exaggerate the number of people at risk. 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